A&E in London's North Middlesex University Hospital is heating up thanks to an aggressive male who claims he has been attacked. Language is a barrier but by a stroke of luck, Advanced Clinical Practitioner Albena translates. The patient is incoherent, threatening, and is a risk to others, so security stand close until his suspected psychosis can be managed.

A+E Departments are seeing alcohol abuse on the rise and in Rotherham an alcohol-dependent patient arrives at the rapid assessment unit after faceplanting onto concrete. The patient is agitated but Dr Alex's primary concern is spinal damage and brain injury. They transfer the patient to resus just in time to intercept a seizure. Time is critical but this patient's behaviour is getting in the way of a life-saving brain scan.

Overnight in Rotherham's A+E always sees regular patients making an appearance. A man has been rushed in, escorted by police with a suspected overdose. Nurse Sophie and the team must race to treat and calm the patient before he begins his usual disruptive shenanigans.

Police bring in an abusive male under arrest who claims he has a racing heart, and two friends arrive in resus who have dislocated each other's shoulders during a friendly wrestle.

A man is rushed in to Majors suffering with a collapsed lung and air is leaking into his chest cavity, a highly abusive patient must be restrained, and a rough sleeper comes in with burnt feet.

Nurse Simone has a drunk patient and his equally drunk friend who have passed out in a cubicle, Nurse Sheena must examine a 50-year-old man's puncture wounds from a dog attack. Dr Kaylee is working quickly to investigate a suspected broken ankle, and Dr Luke is concerned with a patients breathing difficulties, who has been brought into resus in a diabetic coma.

In Tunbridge Wells A&E an ambulance crew bring in a patient who is behaving aggressively, sister Geraldine calls security, but the patient takes off, refusing treatment. At North Middlesex University Hospital, a patient's heart stops beating, so the team tries to save their life and maintain blood flow to the brain. At the North London Emergency Department, a 45-year-old suffers life-threatening anaphylaxis from an allergic reaction.

In Rotherham's A&E a patient with a suspected head injury is under arrest in the car park. In London, an eye injury from mixing concrete requires action to prevent permanent damage.