In 1991, a woman is found murdered inside a Nashville motel room; the investigation escalates after Detective Postiglione discovers a similar crime scene in Cincinnati, sending him on a yearlong odyssey to capture a serial killer.

In 1993, a night clerk is shot dead inside the lobby of a hotel. Despite eyewitness accounts, Det. Postiglione can't locate the killer. Recalling subtle clues left outside the crime scene, he finally comes face to face with a most unusual suspect.

A young mother, Vanessa Rucker, is murdered while her children are in the other room, and her body is found in a position that signals sexual assault; the case is put in the hands of an elite unit of homicide investigators.

In 2004, Detective Postiglione investigates the rare double homicide of two young college students in an apartment near a Nashville university; when a third victim is gunned down, Postiglione launches a state-wide manhunt to catch a ruthless killer.

In the middle of the night, Pat is called to the scene of a homicide at The North First Street Truck Stop. Police found the body of the victim just past what the truckers call "Party Row," and quickly identify her by the bracelet with her name on it: Sara Hulbert. Pat and his team comb through surveillance footage, searching for any evidence of the crime. That's when Pat recognizes an unlikely pattern, leading to a race against the clock to apprehend an active killer before he murders again.

Pat learns that one of Nashville's celebrities, former Tennessee Titan quarterback and public hero Steve McNair, has been found dead in his condo. The body of a young female was also present in an apparent double homicide. With a high-profile case on its hands there is only one detective the Chief of Police wants on the case, and that is Det. Pat Postiglione.