Hanyū watches silently and hopelessly as the cruel events occur during the dam incident, while she and Rika eagerly await the arrival of the one person who will be the key element to bring an end to the enemy's intentions.

Takano's story continues, including how she met her foster grandfather, and her determination to continue his work. A few years later, Takano and Hanyū have a very heated confrontation at Oyashiro-sama's shrine.

Takano's past is revealed in disjointed flashbacks, some of them showing her harsh childhood, while others to the time when she became involved with researchers of the Hinamizawa Syndrome.

One after another, Rika's friends are killed while trying to protect her. Takano dissects Rika, but does so without anesthesia, as requested by the latter in an attempt to carve the identity of the culprit behind all the Hinamizawa murders in her mind and prevent the events from this and past worlds from repeating themselves. The villagers are rounded up at the school and gassed to death, while an ecstatic Takano proclaims her ascension to godhood.

After getting a clue of the villain's betrayal, Rika tells her friends the truth behind the Hinamizawa Syndrome, and her connection with it. Meanwhile, the enemy moves on with their plan, eliminating any opposition.

At last, Rika persuades Satoko to ask for help and she is freed from Teppei. However, just when the village seemed to be relieved from its eternal cycle of hatred and death, the real enemies start to act, just like they did in previous worlds.

Keiichi's struggle to help Satoko forces him to confront the village elders, even the leader of the Sonozaki family. As the government succumbs to the pressure of Keiichi and his allies', Satoko's condition is also at its limit.

The fight to save Satoko from her uncle's abuse continues, but they stumble on a dead end because she is reluctant to denounce him, for her own reasons. Rika realizes that despite their, she is the one who must take action.

Rika's plans are hindered by the appearance of Teppei, who much like in "Tatarigoroshi-hen", begins to abuse Satoko. Keiichi and the rest of the gang decide to find a way to release her from his clutches, but the government is reluctant to cooperate.

Influenced by Keiichi's encouragement, and the fact her friends are starting to avoid doing the same mistakes again by remembering glimpses of what they could have done, Rika decides to find a way to prevent her ominous destiny by herself.

Rika begins a new world with Hanyū, but is getting tired of seeing her friends commit the same acts that lead them to terrible mistakes, until Keiichi proves to her that people can change their destinies if they want.

Much to Satoko's surprise, Rika hides her before letting her murderers take her away. After witnessing Rika's demise and the death of the remaining villagers, Satoko fights desperately for her life.

The day of the Watanagashi Festival comes, and once again Rika fails to warn Tomitake of his imminent death. Later, Satoko is convinced that a mysterious man is following her and Rika around, even though no one else has noticed any such thing. Worried of Rika's safety, she sets traps around the house to alert her of any intruders, and when one is triggered, her fears are confirmed.

Satoko worries about Rika's depression and tries to confront her about it, but Rika continues to deny anything is wrong. In the middle of the night, Satoko is woken by Rika arguing with a mysterious voice, and telling her she will soon be murdered, and there is nothing that either of them can do.

Back in June 1983, the club participates in a game of "zombie tag". On their way home, they run into Irie, Tomitake, and Takano, who tell Keiichi about the yearly murders known as "Oyashiro-sama's Curse". However, he understands why his friends hid it from him and doesn't resent them for it. Regardless, this fails to reassure Rika, as she grows progressively depressed as the day of the Watanagashi Festival approaches.

Mamoru Akasaka, with an assistant, visits the abandoned town of Hinamizawa in the year 2007, and meets with Officer Oishi. They still wonder about the Great Hinamizawa Disaster that decimated the town and the connection to Miyo Takano's File No. 34. Rena shares with them the little knowledge she has about Rika's strange behavior, shortly before the supposed "gas leak", and Akasaka recalls his meeting with the young Rika as well.