Phillip is obsessed with cleanliness, yard work, and organization. His OCD makes it almost impossible to spend time with his two children because he's afraid of the messes that kids make. Meanwhile, Kerrie's fear of germs is so extreme that she can't be touched by other people, even her mother. She's never had a boyfriend and has no friends.

Rashawndalynn began to worry about disease and death after a doctor found pre-cancerous cells in her body. Her constant state of panic has led to the loss of her job, and she and her son will become homeless if she doesn't receive treatment. Meanwhile, Melody is terrified of getting a fatal food-borne illness and has a fear of food, which prevents her from living on her own at college.

Paul constantly checks his stove and electrical outlets because he's afraid they may start a fire and kill everyone in his apartment complex. The problem has all but ended his promising musical career. Meanwhile, Robin spends up to 20 hours a day cleaning her house, and even gets her husband and children to join her.

William obsessively counts, fears odd numbers, and suffers from germophobia. His OCD has resulted in two failed marriages, unemployment, and homelessness. Nanci is obsessed with cleaning, and scours her bathroom 4-5 times a day. Her OCD was triggered by three tragic deaths in her family.

Margaret, a mother of a terminally ill child, has become debilitated from extensive tapping compulsions and a fear of food contamination. She eats only an apple every two days, and recently had a heart attack. Meanwhile, Amy is a perfectionist whose cleaning rituals take precedence over taking care of her son.

Mark obsessively taps and counts, believing that it protects his family from harm and even death. Sarihn obsessively cleans her kitchen and bathroom to get rid of germs, particularly bodily fluids, and wears black latex gloves in public. Her OCD has cost her a music career, and keeps her from having an intimate relationship with her boyfriend.

Al and his two daughters, Tammy and Jodi, each suffer from agoraphobia. Al has been virtually homebound for 30 years. Tammy is afraid of leaving her 20-mile safe zone. And for Jodi, the problem is literally a matter of life and death--she can't go over a bridge she needs to cross to get desperately needed medical care for her son.

Sharon obsessively taps and counts and suffers several major panic attacks a week. She believes her rituals protect her cancer-stricken mother. Meanwhile, Patricia constantly fears that she'll die a sudden death from heart attack or stroke, or that she'll get a deadly illness. She's also afraid of hospitals, which makes it impossible to support her husband as he gets treatment for his multiple sclerosis.