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An American Dream becomes a tragedy when San Antonio businesswoman Andreen McDonald goes missing. Four years later, her husband, Air Force Major, Andre McDonald, is on trial for her murder. Facing life in prison, McDonald takes the stand. Will the jury believe he's the victim of a domestic dispute gone wrong or a cold-blooded monster?

During a routine undercover prostitution sting, Columbus Vice Detective Andrew Mitchell shoots and kills 23-year-old Donna Dalton Castleberry. Mitchell takes the stand, claiming he feared for his life but the Prosecution argues that Donna, locked in the backseat of a car, was no longer a threat. An audio recording of the entire incident will prove to be a key piece of evidence. Will the jury decide this was a justified killing?

In 2006, Ken Juedes was found dead by his wife, Cindy Shulz-Juedes. For 13 years the case went cold until investigators linked her to the murder. Cindy Shulz-Juedes has decided to take the stand with the hope of convincing the jury she is innocent, and her husband's real killer is still at large.

Skiing icon Dean Cummings is on trial for the shooting death of Guillermo Arriola, a local New Mexican rancher who was only armed with a can of mace. Cummings claims the shooting was done in self-defense. With no other witnesses, the jury will have to weigh the forensics against Cummings testimony. Will they acquit him or find him guilty of first degree murder?

After the brutal murder of a mom, her children, and the family dog rocks a picture-perfect Orlando suburb--all signs point to the dad, Tony Todt. But Tony's own tear-soaked and unpredictable testimony points to the person you'd least expect, and there is no evidence to prove him wrong. Will Tony Todt be able to convince the jury he did not murder his family?

In 2019 Delinord Dumercy takes the stand for the second time, claiming that his decision to shoot and ultimately kill James Peoples was in self-defense and not murder. Although this horrific event is witnessed by multiple people and captured on camera, Dumercy's first trial ended in a hung jury. Will prosecutors be able to convince a jury that Dumercy is guilty of murder? Or will they find him innocent after he claims that he was being hunted like an animal by James Peoples all along?

Georgia high school teacher Tara Grinstead's sudden disappearance in 2005 goes unexplained for 11 years until a surprising statement to law enforcement from Bo Dukes, a former student, names his friend and former classmate, Ryan Duke, as her killer. Fighting for his freedom, Ryan Duke takes the stand at his trial to assert who he says is the true killer. Will his testimony be enough to convince the jury he didn't murder Tara Grinstead?