Whitman officially takes over from Hurley as the acting Clinical Director, and must endure a very difficult day.Polly is feeling guilty that she got the Clinical Fellowship job on the back of her research into the FSD drug and Rob’s had enough and tells Donna he wants to leave the hospital, that is until he is unfortunately summoned to a secret meeting with Tennant and Hurley, where he is made a very tempting offer.

A patient is re-admitted with heart problem and Whitman is convinced it has to do with the drug trial she's been on. Also, it's exam time for Rob and Polly, however only one of them can get the prestigious Clinical Fellowship. Also, Hurley receives a mystery text message, making him even more paranoid. His mind's not on the job when he fails to recognise the symptoms of a woman with terrible abdomen pain. Later, Harriet turns up at the hospital and tells Hurley he needs to move out for a while.

Polly finds out she’s pregnant and thinks she can deal with it herself.Tim and Whitman perform a termination procedure. When the woman returns with an infection, Tim goes out of his way not to help her. Throughout the day, Whitman is being assessed. The final test is a difficult case requiring excellent operating skills. He impresses Hilary Sachs with an unexpected theatre emergency.Rob has something important he must tell Beth and Donna and everyone wants to know what happened to Hurley and Maya in the hotel room.

Hurley gets his sperm test results back, and it's not good news. Meanwhile, Rob has his hands full with a woman who is pregnant with five babies. He knows that they should go for a selective reduction, but Hurley feels the pressure from management for a media friendly story, and agrees to go with the woman's wishes to try and take the pregnancies to term, despite the risks involved.Hurley and Whitman both speak at a medical symposium, but the real action is in the hotel later that evening involving Hurley and Maya.

The HRPU opens and during the speeches Hurley announces a new Clinical Fellowship position that interests both Rob and Polly. The competition between them soon leads to mistrust. Chrissy approaches Tennant about the anonymous letters she's been receiving but he doesn't take them seriously and the repercussions aren't what Chrissy anticipated. Donna's anger and mistrust towards Hurley is growing. However,Rob stops her from going a bit too far and explains that when the time comes to 'bring him down' it'll be his decision, no one else's.

Donna becomes continues vocalizing her disagreements with Hurley. Chrissy receives anonymous letters about Hurley's negligence and everyone assumes it's Donna. Meanwhile, one of Whitman's patients dies or does she?

Whitman is still holding a grudge against Rob and will not help in a major medical situation. Chrissy is still digging up dirt against Whitman who refuses to operate on a patient in case something goes wrong. Elsewhere, Rob and Donna's relationship proves to be so stressful that Donna turns to Diamorphine for help.

Whitman has gotten on the wrong side of Chrissy after catching him in the female changing room. At the monthly M&M meeting, Hurley places Rob in a position to speak out against Whitman in front of the entire department.