A suspicious looking doctor starts doing the rounds at the hospital. The staff hold a surprise party for Mr. Docherty who is getting married the next day. Caroline is shown to be violently vomiting, and later she tells Andrew that she is pregnant. Raj's father is being treated for a heart attack. Dr. Mortimer is diagnosed with pneumonia. Smedley gets back together with Claire. In the final scenes, Dr. Collin visits Liz Reid, who has previously suffered a mental breakdown. Andrew answers the door to what he thinks is a diabetic patient requiring advice, however the patient suddenly stabs Dr. Collin with a needle containing insulin. Raj realises who the man is, and arrives shortly after to bring the maniac under control. In the meantime Maitland, Smedley, Mortimer and Raj attempt to treat Dr. Collin, whose life is clearly in great danger.

Because of staff shortage Liz hasn't slept for three nights. She is asked to turn off the ventilator of a brain-dead patient (with relatives present) and accidentally presses the wrong button, which triggers a noisy alarm. She later has an argument with a patient. Claire breaks up with Adrian. Julie breaks up with Cyril. Mr. Docherty finally proposes to Mrs. Trimble. Adrian's son comes in after a traffic accident. Adrian tries to save him but fails. Alone in the theatre, he breaks out in tears. Liz has a nervous breakdown in her room, smashing her pager.

David the kidney patient returns again as an emergency case. They have reached end of line with dialysis and he is told that he needs a transplant fairly urgently or he will die. Liz asks Rod to phone for some results. A verbal misunderstanding follows, and Liz tells the patient he doesn't have cancer, however the results are in fact cancer, and Liz is in error of judgement again. A drunk driver and his victim are brought in. In an uncharacteristic act, Smedley deliberately ignores treatment of the drunk driver, although Raj realises in time to save him when Smedley reveals that his wife died from a drunk driver some years before. Sister Novac (above right) questions her relationship with Smedley. Raj gets it together with Kirsty the student nurse.

Sister Pereria (from series 2) returns bringing in her son for treatment. DeVries finds out about the blood group and that the boy is his son. Dr. Mortimer tries to teach Mr. Docherty how to dance! A Wharfarin overdose patient initially refuses treatment with a blood transfusion because he is a Jehovah's Witness. When the patient suffers a stroke, he appears to change his mind, however in a seemingly uncharacteristic act of Dr. Collin, he suddenly tries to persuade the patient to continue to refuse treatment with the blood because of religious beliefs. Liz starts to crack under the pressure.

Mr. Docherty plans on proposing to Mrs. Trimble. In a bad day for Mr. Docherty, he accompanies a patient in an ambulance over to the General, however finds that he does not have a lift to return him afterwards. A boy is admitted and an appendectomy performed. When the child complains of leg pain after the operation, Dr. Mortimer examines the boy, however there is trouble when the boy's (almost unbelievably prejudiced) father learns that it is the HIV positive Mortimer who is treating his son. He demands Mortimer is sacked after making a completely false allegation about Mortimer supposedly touching the boy inappropriately. The nurse who observed Mortimer examining the boy can easily confirm there was nothing untoward in his examination, but is told by Tennant not to back up Dr. Mortimer. Later, Mr. Docherty delves into the incident, and the truth is revealed. Smedley, Novac, Raj and Kirsty try to help three children affected by smoke inhalation. During the procedure, Kirsty is told by

A man and his daughter are brought in after a car accident. The man survives relatively lightly, however the daughter goes on to suffer brain damage. The kidney patient (David) from episode 1 returns, and the issue of organ donation again arises. Despite Claire's personal intervention to try and persuade the man to give his daughter's organs for donation, he refuses

A man covers himself with flammable liquid in casualty and threatens to set himself alight. Sister Novac eventually persuades the man to stop. At the same time a criminal called Binns (accompanied by the police) is brought in with a stab wound. His stab wound is treated and he is supposed to be discharged in a short time, however the wound fails to heal properly. It is revealed later that Binns attempts to put off his discharge from the hospital by deliberately infecting the wound himself. New student nurses start at the hospital, including Kirsty (played by Lisa Harkus). Raj takes a fancy to Kirsty. Dr. Collin treats Edith Channing the Parkinson's patient. At the start of the episode she appears extremely confused and difficult to deal with, although at the end of the episode she has completely transformed for the better. Caroline gives Andrew an ultimatum to leave his wife Alison or they stop seeing each other. Novac and Smedley finally get it together.

This excellent episode interweaves a storyline about shaken baby syndrome with which Dr. Raj deals with, a cricket match between the junior doctors and consultants, and a behind-closed-doors meeting about how to resolve Phil Kirkby's possible manslaughter charge. Phil tells Mr. Docherty the truth about the inquest, and how he was expected to lie to cover Dr. Turner. Mr. Docherty promises to help him. Liz is unsure what to do about basic CPR. Raj talks to Nasreen on the phone, and their relationship starts to come under some strain. Claire tells Sarah Hudson that she thinks that Liz is ""ill motivated, innatentive and manipulative"".