A shooting at a nearby college sends TC, Jordan, Drew and Amira into the field, where they assist Rick with a deadly situation. Scott implements a new training program and locks horns with Julian. Drew struggles with frustrations about going to Army Ranger School while Shannon and TC both contemplate their future at San Antonio Memorial.

TC and Jordan accompany a SWAT team on a raid and wind up with an emergency room full of sickened immigrants, including one with murderous intentions. Scott pulls a dream team together to impress the Colonel in charge of setting up a combat training program. More is learned about Cain's past. Kenny shares some big news with the group, while Shannon keeps something personal from Paul.

When Jordan realizes the hospital is under cyber-attack, she leads the team in managing patient care as chaos ensues. Drew and Kenny treat a critical patient forcing Drew to call on his medical and military training. TC joins Rick and his partner on a SWAT drug raid. Meanwhile, he wrestles with whether or not he should return to Syria to tie up loose ends.

When protestors descend on a funeral for a dear member of the night shift family, multiple veterans are injured and brought to San Antonio Memorial for treatment. A high profile politician from Drew's past triggers flashbacks to his time in Iraq. Jordan, Scott, and TC disagree on how to best provide care for the politician. Paul and Shannon must improvise while tending to Doug, a former POW. Cain and Drew treat a fearless photographer.

Kenny joins Drew at his MMA veteran's support group and finds himself in the fight of his life. Jordan and Cain treat casualties from a hotel fire while Shannon follows a hunch to help save a young victim. Paul's superstar sister, Dr. Bella Cummings, pays a visit to San Antonio Memorial. Meanwhile, TC finally returns home, forcing him to deal with Topher's death.

Drew, his mom, and Rick's flight home turns into a medical crisis at 35,000 feet when passengers become sickened one by one. Jordan, Paul, Shannon, Kenny, and Cain spend their day off at an obstacle course fundraiser for Cystic Fibrosis, hosted by Akbar Gbajabjamila. Scott finds himself on a Tinder date he won't soon forget. Meanwhile, TC puts his own life in danger to operate on a soldier.

When a patient from a distant town journeys to SAM for surgery, Scott commits to helping her against all odds. Jordan and Cain help a wounded veteran come to terms with a diagnosis he doesn't believe he has. Meanwhile, Drew struggles with the exhaustion of being a working parent and finds support from an unusual patient. After a long night, Kenny learns life is too short to worry about trivial matters. TC joins a daring rescue mission in Syria.

Jordan and Cain figure out their professional dynamic as they work on a patient with extreme injuries from an oil field explosion. Drew and Paul receive a patient from the same accident, and must figure out a solution to save the patient's severed hand. Scott is caught off guard when Annie shows up to the hospital with an unexpected guest from his past. Kenny and Shannon struggle to adjust to their new living situation. Meanwhile, TC and Amira clash over treating a Syrian child on the American base.